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Dactinomycin

"Dactinomycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information
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A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)


publications
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This graph shows the total number of publications written about "Dactinomycin" by people in Harvard Catalyst Profiles by year, and whether "Dactinomycin" was a major or minor topic of these publication.
Bar chart showing 127 publications over 29 distinct years, with a maximum of 8 publications in 1994 and 1995 and 1998 and 2003
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.