Harvard Catalyst Profiles

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Dactinomycin

"Dactinomycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)


This graph shows the total number of publications written about "Dactinomycin" by people in Harvard Catalyst Profiles by year, and whether "Dactinomycin" was a major or minor topic of these publication.
Bar chart showing 165 publications over 30 distinct years, with a maximum of 14 publications in 1991
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.