"DNA, Superhelical" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Circular duplex DNA isolated from viruses, bacteria and mitochondria in supercoiled or supertwisted form. This superhelical DNA is endowed with free energy. During transcription, the magnitude of RNA initiation is proportional to the DNA superhelicity.
MeSH Number(s)
D13.444.308.283.250
G02.111.570.790.486.212.250
G05.360.580.156.250
Concept/Terms
DNA, Superhelical- DNA, Superhelical
- Superhelical DNA
- DNA, Supertwisted
- Supertwisted DNA
- DNA, Supercoiled
- Supercoiled DNA
Below are MeSH descriptors whose meaning is more general than "DNA, Superhelical".
Below are MeSH descriptors whose meaning is more specific than "DNA, Superhelical".
This graph shows the total number of publications written about "DNA, Superhelical" by people in Harvard Catalyst Profiles by year, and whether "DNA, Superhelical" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 0 | 1 |
| 1994 | 1 | 0 | 1 |
| 1995 | 1 | 0 | 1 |
| 1996 | 2 | 2 | 4 |
| 1997 | 1 | 1 | 2 |
| 1998 | 1 | 0 | 1 |
| 1999 | 3 | 1 | 4 |
| 2000 | 0 | 4 | 4 |
| 2001 | 0 | 1 | 1 |
| 2003 | 1 | 1 | 2 |
| 2005 | 1 | 0 | 1 |
| 2008 | 2 | 0 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2022 | 3 | 0 | 3 |
Below are the most recent publications written about "DNA, Superhelical" by people in Profiles.
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Collective polymerase dynamics emerge from DNA supercoiling during transcription. Biophys J. 2022 11 01; 121(21):4153-4165.
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On the stability of stalled RNA polymerase and its removal by RapA. Nucleic Acids Res. 2022 07 22; 50(13):7396-7405.
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Psoralen mapping reveals a bacterial genome supercoiling landscape dominated by transcription. Nucleic Acids Res. 2022 05 06; 50(8):4436-4449.
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The Stringent Response Inhibits DNA Replication Initiation in E. coli by Modulating Supercoiling of oriC. mBio. 2019 07 02; 10(4).
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A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to Stimulate Type II Topoisomerases and Enable DNA Replication. Cell. 2018 10 04; 175(2):583-597.e23.
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Properties of gene expression and chromatin structure with mechanically regulated elongation. Nucleic Acids Res. 2018 07 06; 46(12):5924-5934.
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Biophysical Constraints Arising from Compositional Context in Synthetic Gene Networks. Cell Syst. 2017 07 26; 5(1):11-24.e12.
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Mechanical Properties of Transcription. Phys Rev Lett. 2017 Jun 30; 118(26):268101.
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Annealing helicase HARP closes RPA-stabilized DNA bubbles non-processively. Nucleic Acids Res. 2017 05 05; 45(8):4687-4695.
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Mechanical bounds to transcriptional noise. Proc Natl Acad Sci U S A. 2016 12 06; 113(49):13983-13988.