DNA Topoisomerases, Type II
"DNA Topoisomerases, Type II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.
Concept/Terms
DNA Topoisomerases, Type II- DNA Topoisomerases, Type II
- DNA Topoisomerase II
- Topoisomerase II
- Type II DNA Topoisomerase
- DNA Topoisomerase (ATP-Hydrolysing)
- DNA Type 2 Topoisomerase
Below are MeSH descriptors whose meaning is more general than "DNA Topoisomerases, Type II".
Below are MeSH descriptors whose meaning is more specific than "DNA Topoisomerases, Type II".
This graph shows the total number of publications written about "DNA Topoisomerases, Type II" by people in Harvard Catalyst Profiles by year, and whether "DNA Topoisomerases, Type II" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 4 | 1 | 5 |
| 1995 | 3 | 2 | 5 |
| 1996 | 4 | 0 | 4 |
| 1997 | 2 | 1 | 3 |
| 1998 | 4 | 2 | 6 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 2 | 3 |
| 2001 | 4 | 0 | 4 |
| 2002 | 1 | 1 | 2 |
| 2003 | 0 | 1 | 1 |
| 2005 | 1 | 1 | 2 |
| 2006 | 0 | 1 | 1 |
| 2008 | 2 | 3 | 5 |
| 2009 | 3 | 0 | 3 |
| 2010 | 3 | 2 | 5 |
| 2011 | 5 | 2 | 7 |
| 2012 | 2 | 2 | 4 |
| 2013 | 1 | 1 | 2 |
| 2015 | 1 | 2 | 3 |
| 2016 | 3 | 0 | 3 |
| 2017 | 2 | 1 | 3 |
| 2018 | 1 | 2 | 3 |
| 2019 | 3 | 0 | 3 |
| 2020 | 2 | 2 | 4 |
| 2021 | 3 | 0 | 3 |
| 2022 | 0 | 2 | 2 |
Below are the most recent publications written about "DNA Topoisomerases, Type II" by people in Profiles.
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TOPBPing up DSBs with PARylation. Mol Cell. 2022 07 21; 82(14):2538-2540.
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Exploration of mercaptoacetamide-linked pyrimidine-1,3,4-oxadiazole derivatives as DNA intercalative topo II inhibitors: Cytotoxicity and apoptosis induction. Bioorg Med Chem Lett. 2022 06 01; 65:128697.
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Topoisomerase II alpha inhibition can overcome taxane-resistant prostate cancer through DNA repair pathways. Sci Rep. 2021 11 15; 11(1):22284.
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The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma. Nat Commun. 2021 11 09; 12(1):6468.
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BRCA1-BARD1 regulates transcription through modulating topoisomerase IIß. Open Biol. 2021 10; 11(10):210221.
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Development of ß-carboline-benzothiazole hybrids via carboxamide formation as cytotoxic agents: DNA intercalative topoisomerase IIa inhibition and apoptosis induction. Bioorg Chem. 2021 01; 106:104481.
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Design and synthesis of thiadiazolo-carboxamide bridged ß-carboline-indole hybrids: DNA intercalative topo-IIa inhibition with promising antiproliferative activity. Bioorg Chem. 2020 12; 105:104357.
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The 3D Topography of Mitotic Chromosomes. Mol Cell. 2020 09 17; 79(6):902-916.e6.
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The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning. Proc Natl Acad Sci U S A. 2020 02 25; 117(8):4053-4060.
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GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability. Dev Cell. 2020 01 06; 52(1):53-68.e6.