Harvard Catalyst Profiles

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DNA Topoisomerase IV

"DNA Topoisomerase IV" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication.


This graph shows the total number of publications written about "DNA Topoisomerase IV" by people in Harvard Catalyst Profiles by year, and whether "DNA Topoisomerase IV" was a major or minor topic of these publication.
Bar chart showing 32 publications over 17 distinct years, with a maximum of 5 publications in 2005
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.