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DNA Damage

"DNA Damage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.


This graph shows the total number of publications written about "DNA Damage" by people in Harvard Catalyst Profiles by year, and whether "DNA Damage" was a major or minor topic of these publication.
Bar chart showing 1589 publications over 31 distinct years, with a maximum of 98 publications in 2013
To see the data from this visualization as text, click here.
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