Cystathionine gamma-Lyase
"Cystathionine gamma-Lyase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multifunctional pyridoxal phosphate enzyme. In the final step in the biosynthesis of cysteine it catalyzes the cleavage of cystathionine to yield cysteine, ammonia, and 2-ketobutyrate. EC 4.4.1.1.
Concept/Terms
Cystathionine gamma-Lyase- Cystathionine gamma-Lyase
- Cystathionine gamma Lyase
- gamma-Lyase, Cystathionine
- Cystine Desulfhydrase
- Desulfhydrase, Cystine
- Cysteine Desulfhydrase
- Desulfhydrase, Cysteine
- gamma-Cystathionase
- gamma Cystathionase
- Homoserine Deaminase
- Deaminase, Homoserine
- Homoserine Dehydratase
- Dehydratase, Homoserine
- Cystathionase
- Cystine Desulfohydrolase
- Desulfohydrolase, Cystine
Below are MeSH descriptors whose meaning is more general than "Cystathionine gamma-Lyase".
Below are MeSH descriptors whose meaning is more specific than "Cystathionine gamma-Lyase".
This graph shows the total number of publications written about "Cystathionine gamma-Lyase" by people in Harvard Catalyst Profiles by year, and whether "Cystathionine gamma-Lyase" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2009 | 1 | 1 | 2 |
| 2013 | 2 | 0 | 2 |
| 2014 | 0 | 2 | 2 |
| 2017 | 0 | 2 | 2 |
| 2018 | 0 | 2 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
Below are the most recent publications written about "Cystathionine gamma-Lyase" by people in Profiles.
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Sodium thiosulfate acts as a hydrogen sulfide mimetic to prevent intimal hyperplasia via inhibition of tubulin polymerisation. EBioMedicine. 2022 Apr; 78:103954.
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Cystathionine-gamma-lyase overexpression in T cells enhances antitumor effect independently of cysteine autonomy. Cancer Sci. 2021 May; 112(5):1723-1734.
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Cysteine depletion induces pancreatic tumor ferroptosis in mice. Science. 2020 04 03; 368(6486):85-89.
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Short-term preoperative protein restriction attenuates vein graft disease via induction of cystathionine ?-lyase. Cardiovasc Res. 2020 02 01; 116(2):416-428.
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The endogenous hydrogen sulfide generating system regulates ovulation. Free Radic Biol Med. 2019 07; 138:43-52.
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Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production. Cell. 2018 03 22; 173(1):117-129.e14.
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Anti-CD73 and anti-OX40 immunotherapy coupled with a novel biocompatible enzyme prodrug system for the treatment of recurrent, metastatic ovarian cancer. Cancer Lett. 2018 07 01; 425:174-182.
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Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell Metab. 2017 Jun 06; 25(6):1320-1333.e5.
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Complementary roles of gasotransmitters CO and H2S in sleep apnea. Proc Natl Acad Sci U S A. 2017 02 07; 114(6):1413-1418.
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Redox Signaling Regulated by Cysteine Persulfide and Protein Polysulfidation. Molecules. 2016 Dec 15; 21(12).