Harvard Catalyst Profiles

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Complementarity Determining Regions

"Complementarity Determining Regions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

Three regions (CDR1; CDR2 and CDR3) of amino acid sequence in the IMMUNOGLOBULIN VARIABLE REGION that are highly divergent. Together the CDRs from the light and heavy immunoglobulin chains form a surface that is complementary to the antigen. These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors (RECEPTORS, ANTIGEN, T-CELL).


This graph shows the total number of publications written about "Complementarity Determining Regions" by people in Harvard Catalyst Profiles by year, and whether "Complementarity Determining Regions" was a major or minor topic of these publication.
Bar chart showing 79 publications over 22 distinct years, with a maximum of 6 publications in 2001 and 2009 and 2011 and 2013 and 2015
To see the data from this visualization as text, click here.
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.