Harvard Catalyst Profiles

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Complement Pathway, Classical

"Complement Pathway, Classical" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the sequential activation of COMPLEMENT C1R and COMPLEMENT C1S subunits. Activated C1s cleaves COMPLEMENT C4 and COMPLEMENT C2 forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.


This graph shows the total number of publications written about "Complement Pathway, Classical" by people in Harvard Catalyst Profiles by year, and whether "Complement Pathway, Classical" was a major or minor topic of these publication.
Bar chart showing 50 publications over 21 distinct years, with a maximum of 4 publications in 2000 and 2005 and 2006 and 2011 and 2014 and 2016
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.