Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Complement Pathway, Alternative

"Complement Pathway, Alternative" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

Complement activation initiated by the interaction of microbial ANTIGENS with COMPLEMENT C3B. When COMPLEMENT FACTOR B binds to the membrane-bound C3b, COMPLEMENT FACTOR D cleaves it to form alternative C3 CONVERTASE (C3BBB) which, stabilized by COMPLEMENT FACTOR P, is able to cleave multiple COMPLEMENT C3 to form alternative C5 CONVERTASE (C3BBB3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.


This graph shows the total number of publications written about "Complement Pathway, Alternative" by people in Harvard Catalyst Profiles by year, and whether "Complement Pathway, Alternative" was a major or minor topic of these publication.
Bar chart showing 61 publications over 25 distinct years, with a maximum of 5 publications in 2011 and 2013 and 2014
To see the data from this visualization as text, click here.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.