"Complement C4b" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The large fragment formed when COMPLEMENT C4 is cleaved by COMPLEMENT C1S. The membrane-bound C4b binds COMPLEMENT C2A, a SERINE PROTEASE, to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).
MeSH Number(s)
D12.776.124.486.274.350.260
Concept/Terms
Complement C4b- Complement C4b
- C4b, Complement
- Complement 4b
- Complement Component 4b
- Component 4b, Complement
- C4b Complement
- Complement, C4b
Below are MeSH descriptors whose meaning is more general than "Complement C4b".
Below are MeSH descriptors whose meaning is more specific than "Complement C4b".
This graph shows the total number of publications written about "Complement C4b" by people in Harvard Catalyst Profiles by year, and whether "Complement C4b" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1997 | 1 | 1 | 2 |
| 1999 | 4 | 0 | 4 |
| 2000 | 1 | 0 | 1 |
| 2001 | 4 | 0 | 4 |
| 2002 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 1 | 3 | 4 |
| 2006 | 3 | 0 | 3 |
| 2007 | 2 | 2 | 4 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 2 | 2 |
| 2010 | 1 | 2 | 3 |
| 2011 | 1 | 1 | 2 |
| 2012 | 2 | 4 | 6 |
| 2013 | 2 | 3 | 5 |
| 2014 | 3 | 1 | 4 |
| 2015 | 1 | 0 | 1 |
| 2016 | 2 | 0 | 2 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 1 | 2 |
| 2020 | 1 | 1 | 2 |
| 2023 | 2 | 0 | 2 |
Below are the most recent publications written about "Complement C4b" by people in Profiles.
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Bioengineered 3D Skeletal Muscle Model Reveals Complement 4b as a Cell-Autonomous Mechanism of Impaired Regeneration with Aging. Adv Mater. 2023 Apr; 35(17):e2207443.
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Targeting therapeutic agent against C3b/C4b, SB002, on the inflammation-induced bone loss in experimental periodontitis. J Clin Periodontol. 2023 05; 50(5):657-670.
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Complement C4A Regulates Autoreactive B Cells in Murine Lupus. Cell Rep. 2020 11 03; 33(5):108330.
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An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase. J Immunol. 2020 09 15; 205(6):1678-1694.
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Complement Activation in Patients With Probable Systemic Lupus Erythematosus and Ability to Predict Progression to American College of Rheumatology-Classified Systemic Lupus Erythematosus. Arthritis Rheumatol. 2020 01; 72(1):78-88.
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Graft vasculopathy of vascularized composite allografts in humans: a literature review and retrospective study. Transpl Int. 2019 Aug; 32(8):831-838.
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Desensitization and Prevention of Antibody-Mediated Rejection in Vascularized Composite Allotransplantation by Syngeneic Hematopoietic Stem Cell Transplantation. Transplantation. 2018 04; 102(4):593-600.
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The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology. Am J Transplant. 2017 01; 17(1):28-41.
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Complement Activation in Trauma Patients Alters Platelet Function. Shock. 2016 09; 46(3 Suppl 1):83-8.
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C4 Glomerulopathy: A Disease Entity Associated With C4d Deposition. Am J Kidney Dis. 2016 Jun; 67(6):949-53.