Complement C4a

"Complement C4a" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The smaller fragment formed when complement C4 is cleaved by COMPLEMENT C1S. It is an anaphylatoxin that causes symptoms of immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE) but its activity is weaker than that of COMPLEMENT C3A or COMPLEMENT C5A.

Descriptor ID

D015934

MeSH Number(s)

D12.776.124.486.274.024.260

D12.776.124.486.274.350.250

Concept/Terms

Complement C4a

Below are MeSH descriptors whose meaning is more general than "Complement C4a".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Immunoproteins [D12.776.124.486]
Complement System Proteins [D12.776.124.486.274]
Anaphylatoxins [D12.776.124.486.274.024]
Complement C4a [D12.776.124.486.274.024.260]
Complement C4 [D12.776.124.486.274.350]
Complement C4a [D12.776.124.486.274.350.250]

Below are MeSH descriptors whose meaning is related to "Complement C4a".

Below are MeSH descriptors whose meaning is more specific than "Complement C4a".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Complement C4a" by people in Harvard Catalyst Profiles by year, and whether "Complement C4a" was a major or minor topic of these publication.

Bar chart showing 6 publications over 5 distinct years, with a maximum of 2 publications in 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	1	0	1
1996	0	1	1
1997	0	1	1
2020	1	0	1
2022	0	2	2

Below are the most recent publications written about "Complement C4a" by people in Profiles.

Cerebrospinal fluid concentration of complement component 4A is increased in first episode schizophrenia. Nat Commun. 2022 11 03; 13(1):6427.

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Low copy numbers of complement C4 and C4A deficiency are risk factors for myositis, its subgroups and autoantibodies. Ann Rheum Dis. 2023 Feb; 82(2):235-245.

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Complement C4A Regulates Autoreactive B Cells in Murine Lupus. Cell Rep. 2020 11 03; 33(5):108330.

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MHC region and risk of systemic lupus erythematosus in African American women. Hum Genet. 2011 Dec; 130(6):807-15.

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The use of ultrafiltration for inflammatory mediators removal during cardiopulmonary bypass in coronary artery bypass graf surgery. Rev Bras Cir Cardiovasc. 2008 Apr-Jun; 23(2):175-82.

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HLA-B44031;DRB1*1503 and other sub-Saharan African major histocompatibility complex haplotypes in African Americans and Afro-Caribbeans carry C4A gene deletions: implications for ethnicity-specific lupus susceptibility genes. Arthritis Rheum. 2000 Oct; 43(10):2378-9.

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Relationship between protein complotypes and DNA variant haplotypes: complotype-RFLP constellations (CRC). Hum Immunol. 1997 Sep 15; 57(1):27-36.

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Alkylation of cellulosic membranes results in reduced complement activation. J Biomater Sci Polym Ed. 1996; 7(8):707-14.

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Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C4B genes in the HLA class III region. Molecular cloning, exon-intron structure, composite retroposon, and breakpoint of gene duplication. J Biol Chem. 1994 Mar 18; 269(11):8466-76.

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A single arginine to tryptophan interchange at beta-chain residue 458 of human complement component C4 accounts for the defect in classical pathway C5 convertase activity of allotype C4A6. Implications for the location of a C5 binding site in C4. J Immunol. 1992 May 01; 148(9):2803-11.

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