"Complement C3b" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The larger fragment generated from the cleavage of COMPLEMENT C3 by C3 CONVERTASE. It is a constituent of the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb), and COMPLEMENT C5 CONVERTASES in both the classical (C4b2a3b) and the alternative (C3bBb3b) pathway. C3b participates in IMMUNE ADHERENCE REACTION and enhances PHAGOCYTOSIS. It can be inactivated (iC3b) or cleaved by various proteases to yield fragments such as COMPLEMENT C3C; COMPLEMENT C3D; C3e; C3f; and C3g.
MeSH Number(s)
D12.776.124.486.274.250.260
Concept/Terms
Complement C3b- Complement C3b
- C3b, Complement
- Complement Component 3b
- Component 3b, Complement
- C3b Complement
- Complement, C3b
- Complement 3b
Below are MeSH descriptors whose meaning is more general than "Complement C3b".
Below are MeSH descriptors whose meaning is more specific than "Complement C3b".
This graph shows the total number of publications written about "Complement C3b" by people in Harvard Catalyst Profiles by year, and whether "Complement C3b" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 |
| 1994 | 2 | 0 | 2 |
| 1996 | 0 | 1 | 1 |
| 1997 | 1 | 3 | 4 |
| 1998 | 0 | 1 | 1 |
| 1999 | 2 | 2 | 4 |
| 2000 | 0 | 3 | 3 |
| 2006 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2012 | 2 | 1 | 3 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 2 | 2 |
| 2015 | 1 | 2 | 3 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2020 | 1 | 1 | 2 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
Below are the most recent publications written about "Complement C3b" by people in Profiles.
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Targeting therapeutic agent against C3b/C4b, SB002, on the inflammation-induced bone loss in experimental periodontitis. J Clin Periodontol. 2023 05; 50(5):657-670.
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Complement-regulatory biomaterial coatings: Activity and selectivity profile of the factor H-binding peptide 5C6. Acta Biomater. 2023 01 01; 155:123-138.
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Complement Receptor 3 Forms a Compact High-Affinity Complex with iC3b. J Immunol. 2021 06 15; 206(12):3032-3042.
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A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity. J Immunol. 2020 10 15; 205(8):2287-2300.
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Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. Nature. 2020 12; 588(7838):459-465.
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Structural Implications for the Formation and Function of the Complement Effector Protein iC3b. J Immunol. 2017 04 15; 198(8):3326-3335.
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Properdin and factor H production by human dendritic cells modulates their T-cell stimulatory capacity and is regulated by IFN-?. Eur J Immunol. 2017 03; 47(3):470-480.
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Structural Basis for Simvastatin Competitive Antagonism of Complement Receptor 3. J Biol Chem. 2016 08 12; 291(33):16963-76.
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The Staphylococcus aureus polysaccharide capsule and Efb-dependent fibrinogen shield act in concert to protect against phagocytosis. Microbiology (Reading). 2016 07; 162(7):1185-1194.
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Mutational analysis of Kaposica reveals that bridging of MG2 and CUB domains of target protein is crucial for the cofactor activity of RCA proteins. Proc Natl Acad Sci U S A. 2015 Oct 13; 112(41):12794-9.