Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Complement C1s

"Complement C1s" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

A 77-kDa subcomponent of complement C1, encoded by gene C1S, is a SERINE PROTEASE existing as a proenzyme (homodimer) in the intact complement C1 complex. Upon the binding of COMPLEMENT C1Q to antibodies, the activated COMPLEMENT C1R cleaves C1s into two chains, A (heavy) and B (light, the serine protease), linked by disulfide bonds yielding the active C1s. The activated C1s, in turn, cleaves COMPLEMENT C2 and COMPLEMENT C4 to form C4b2a (CLASSICAL C3 CONVERTASE).


This graph shows the total number of publications written about "Complement C1s" by people in Harvard Catalyst Profiles by year, and whether "Complement C1s" was a major or minor topic of these publication.
Bar chart showing 7 publications over 7 distinct years, with a maximum of 1 publications in 1992 and 1994 and 1996 and 2001 and 2008 and 2017 and 2021
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.