Compassionate Use Trials

"Compassionate Use Trials" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Providing an investigational therapy to a patient who is not eligible to receive that therapy in a clinical trial, but who has a serious or life-threatening illness for which other treatments are not available. Compassionate use trials allow patients to receive promising but not yet fully studied or approved therapies when no other treatment option exists. Also called expanded access trial.

Descriptor ID

D057176

MeSH Number(s)

E02.931.500

E05.337.300.199

Concept/Terms

Compassionate Use Trials

Humanitarian Device Exemption

Compassionate Use

Below are MeSH descriptors whose meaning is more general than "Compassionate Use Trials".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Therapeutics [E02]
Therapies, Investigational [E02.931]
Compassionate Use Trials [E02.931.500]
Investigative Techniques [E05]
Evaluation Studies as Topic [E05.337]
Drug Approval [E05.337.300]
Compassionate Use Trials [E05.337.300.199]

Below are MeSH descriptors whose meaning is related to "Compassionate Use Trials".

Below are MeSH descriptors whose meaning is more specific than "Compassionate Use Trials".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Compassionate Use Trials" by people in Harvard Catalyst Profiles by year, and whether "Compassionate Use Trials" was a major or minor topic of these publication.

Bar chart showing 25 publications over 9 distinct years, with a maximum of 4 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2010	1	1	2
2012	0	2	2
2013	1	2	3
2014	1	2	3
2015	1	2	3
2016	3	0	3
2017	0	3	3
2018	3	1	4
2020	1	1	2

Below are the most recent publications written about "Compassionate Use Trials" by people in Profiles.

Rubin EJ, Baden LR, Morrissey S. Audio Interview: Caring for Patients with Covid-19. N Engl J Med. 2020 Apr 16; 382(16):e50.

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Atluri S, Manchikanti L, Hirsch JA. Expanded Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) as a Therapeutic Strategy in Managing Critically Ill COVID-19 Patients: The Case for Compassionate Use. Pain Physician. 2020 03; 23(2):E71-E83.

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Borysowski J, Górski A. Compassionate use of unauthorized drugs: Legal regulations and ethical challenges. Eur J Intern Med. 2019 Jul; 65:12-16.

View in: PubMed
Lynch HF, Zettler PJ, Sarpatwari A. Promoting Patient Interests in Implementing the Federal Right to Try Act. JAMA. 2018 Sep 04; 320(9):869-870.

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Einstein DJ. Compassion and Compassionate Use. J Clin Oncol. 2018 10 10; 36(29):2969-2971.

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Jung E, Zettler PJ, Kesselheim AS. Prevalence of Publicly Available Expanded Access Policies. Clin Pharmacol Ther. 2018 11; 104(5):1016-1021.

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McAnaw S, Rodriguez CA, Muller A, Mitnick C, Horsburgh CR. Has compassionate use ever sunk a drug? Int J Tuberc Lung Dis. 2018 02 01; 22(2):119-120.

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Alturki AY, Enriquez-Marulanda A, Schmalz P, Ogilvy CS, Thomas AJ. Transarterial Onyx Embolization of Bilateral Transverse-Sigmoid Dural Arteriovenous Malformation with Transvenous Balloon Assist-Initial U.S. Experience with Copernic RC Venous Remodeling Balloon. World Neurosurg. 2018 Jan; 109:398-402.

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Borysowski J, Ehni HJ, Górski A. Ethics review in compassionate use. BMC Med. 2017 07 24; 15(1):136.

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Kurolap A, Eshach-Adiv O, Hershkovitz T, Paperna T, Mory A, Oz-Levi D, Zohar Y, Mandel H, Chezar J, Azoulay D, Peleg S, Half EE, Yahalom V, Finkel L, Weissbrod O, Geiger D, Tabib A, Shaoul R, Magen D, Bonstein L, Mevorach D, Baris HN. Loss of CD55 in Eculizumab-Responsive Protein-Losing Enteropathy. N Engl J Med. 2017 07 06; 377(1):87-89.

View in: PubMed

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