Comet Assay

"Comet Assay" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A genotoxicological technique for measuring DNA damage in an individual cell using single-cell gel electrophoresis. Cell DNA fragments assume a "comet with tail" formation on electrophoresis and are detected with an image analysis system. Alkaline assay conditions facilitate sensitive detection of single-strand damage.

Descriptor ID

D020552

MeSH Number(s)

E05.196.401.153.150

E05.301.300.100.150

E05.393.560.150

E05.940.560.150

Concept/Terms

Comet Assay

Alkaline Comet Assay

Below are MeSH descriptors whose meaning is more general than "Comet Assay".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Chemistry Techniques, Analytical [E05.196]
Electrophoresis [E05.196.401]
Electrophoresis, Agar Gel [E05.196.401.153]
Comet Assay [E05.196.401.153.150]
Electrochemical Techniques [E05.301]
Electrophoresis [E05.301.300]
Electrophoresis, Agar Gel [E05.301.300.100]
Comet Assay [E05.301.300.100.150]
Genetic Techniques [E05.393]
Mutagenicity Tests [E05.393.560]
Comet Assay [E05.393.560.150]
Toxicity Tests [E05.940]
Mutagenicity Tests [E05.940.560]
Comet Assay [E05.940.560.150]

Below are MeSH descriptors whose meaning is related to "Comet Assay".

Below are MeSH descriptors whose meaning is more specific than "Comet Assay".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Comet Assay" by people in Harvard Catalyst Profiles by year, and whether "Comet Assay" was a major or minor topic of these publication.

Below are the most recent publications written about "Comet Assay" by people in Profiles.

Genotoxicity mechanism of food preservative propionic acid in the in vivo Drosophila model: gut damage, oxidative stress, cellular immune response and DNA damage. Toxicol Mech Methods. 2023 May; 33(4):327-336.

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Systematic review on primary and secondary genotoxicity of carbon black nanoparticles in mammalian cells and animals. Mutat Res Rev Mutat Res. 2022 Jul-Dec; 790:108441.

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In vivo effects of 1,4-dioxane on genotoxic parameters and behavioral alterations in Drosophila melanogaster. J Toxicol Environ Health A. 2022 05 19; 85(10):414-430.

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CometChip analysis of human primary lymphocytes enables quantification of inter-individual differences in the kinetics of repair of oxidative DNA damage. Free Radic Biol Med. 2021 10; 174:89-99.

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Pulmonary toxicity of synthetic amorphous silica - effects of porosity and copper oxide doping. Nanotoxicology. 2021 02; 15(1):96-113.

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A DNA Repair Inhibitor Isolated from an Ecuadorian Fungal Endophyte Exhibits Synthetic Lethality in PTEN-Deficient Glioblastoma. J Nat Prod. 2020 06 26; 83(6):1899-1908.

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Molecular Insights Into Di(2-Picolyl) Amine-Induced Cytotoxicity and Apoptosis in Human Kidney (HEK293) Cells. Int J Toxicol. 2020 Jul/Aug; 39(4):341-351.

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Interference of Hemoglobin A1c Due to Hemoglobin Franklin Park. J Appl Lab Med. 2019 03; 3(5):911-913.

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ST6Gal-I sialyltransferase promotes chemoresistance in pancreatic ductal adenocarcinoma by abrogating gemcitabine-mediated DNA damage. J Biol Chem. 2018 01 19; 293(3):984-994.

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A randomized placebo-controlled pilot study of N-acetylcysteine in youth with autism spectrum disorder. Mol Autism. 2016; 7:26.

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