Harvard Catalyst Profiles

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Colorectal Neoplasms, Hereditary Nonpolyposis

"Colorectal Neoplasms, Hereditary Nonpolyposis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.

This graph shows the total number of publications written about "Colorectal Neoplasms, Hereditary Nonpolyposis" by people in Harvard Catalyst Profiles by year, and whether "Colorectal Neoplasms, Hereditary Nonpolyposis" was a major or minor topic of these publication.
Bar chart showing 207 publications over 29 distinct years, with a maximum of 15 publications in 2011
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.