Coformycin

"Coformycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.

Descriptor ID

D003070

MeSH Number(s)

D03.383.742.680.350.200

D13.570.685.350.200

D13.570.800.410.200

Concept/Terms

Coformycin

Below are MeSH descriptors whose meaning is more general than "Coformycin".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, 1-Ring [D03.383]
Pyrimidines [D03.383.742]
Pyrimidine Nucleosides [D03.383.742.680]
Formycins [D03.383.742.680.350]
Coformycin [D03.383.742.680.350.200]
Nucleic Acids, Nucleotides, and Nucleosides [D13]
Nucleosides [D13.570]
Pyrimidine Nucleosides [D13.570.685]
Formycins [D13.570.685.350]
Coformycin [D13.570.685.350.200]
Ribonucleosides [D13.570.800]
Formycins [D13.570.800.410]
Coformycin [D13.570.800.410.200]

Below are MeSH descriptors whose meaning is related to "Coformycin".

Below are MeSH descriptors whose meaning is more specific than "Coformycin".

Coformycin
Pentostatin

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Coformycin" by people in Harvard Catalyst Profiles by year, and whether "Coformycin" was a major or minor topic of these publication.

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Below are the most recent publications written about "Coformycin" by people in Profiles.

Structural basis for the growth factor activity of human adenosine deaminase ADA2. J Biol Chem. 2010 Apr 16; 285(16):12367-77.

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Dominant localization of adenosine deaminase in leptomeninges and involvement of the enzyme in sleep. Biochem Biophys Res Commun. 2003 Dec 05; 312(1):29-34.

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Deoxycoformycin-induced immunosuppression in patients with hairy cell leukemia. Blood. 1989 Jan; 73(1):38-46.

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Serum soluble IL-2 receptor as a tumor marker in patients with hairy cell leukemia. Blood. 1988 May; 71(5):1304-9.

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Remissions in hairy-cell leukemia with pentostatin (2'-deoxycoformycin). N Engl J Med. 1987 Apr 02; 316(14):825-30.

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Response to 2'-deoxycoformycin after failure of interferon-alpha in nonsplenectomized patients with hairy cell leukemia. Blood. 1986 Jul; 68(1):297-300.

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Herpes simplex virus mutants resistant to arabinosyladenine in the presence of deoxycoformycin. Antimicrob Agents Chemother. 1984 Sep; 26(3):382-7.

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T-lymphocyte malignancies: recent advances in the understanding of their biology, diagnosis and treatment. Clin Immunol Rev. 1983; 2(1):59-121.

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Clinical pharmacology of arabinofuranosyladenine in combination with deoxycoformycin. Cancer Chemother Pharmacol. 1983; 10(2):125-8.

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Clinical pharmacology of 9-beta-D-arabinofuranosyladenine in combination with 2'-deoxycoformycin. Cancer Res. 1982 Sep; 42(9):3884-6.

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