Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Cisplatin

"Cisplatin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.


This graph shows the total number of publications written about "Cisplatin" by people in Harvard Catalyst Profiles by year, and whether "Cisplatin" was a major or minor topic of these publication.
Bar chart showing 928 publications over 31 distinct years, with a maximum of 56 publications in 2013
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.