"Chromosome Walking" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A technique with which an unknown region of a chromosome can be explored. It is generally used to isolate a locus of interest for which no probe is available but that is known to be linked to a gene which has been identified and cloned. A fragment containing a known gene is selected and used as a probe to identify other overlapping fragments which contain the same gene. The nucleotide sequences of these fragments can then be characterized. This process continues for the length of the chromosome.
Concept/Terms
Chromosome Walking- Chromosome Walking
- Chromosome Walkings
- Walking, Chromosome
- Walkings, Chromosome
Below are MeSH descriptors whose meaning is more general than "Chromosome Walking".
Below are MeSH descriptors whose meaning is more specific than "Chromosome Walking".
This graph shows the total number of publications written about "Chromosome Walking" by people in Harvard Catalyst Profiles by year, and whether "Chromosome Walking" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1995 | 1 | 4 | 5 |
| 1996 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
Below are the most recent publications written about "Chromosome Walking" by people in Profiles.
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Walking along chromosomes with super-resolution imaging, contact maps, and integrative modeling. PLoS Genet. 2018 12; 14(12):e1007872.
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Abnormal dosage of ultraconserved elements is highly disfavored in healthy cells but not cancer cells. PLoS Genet. 2014 Oct; 10(10):e1004646.
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Characterization of the chromosomal translocation t(10;17)(q22;p13) in clear cell sarcoma of kidney. J Pathol. 2012 May; 227(1):72-80.
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Chromosomal rearrangements maintain a polymorphic supergene controlling butterfly mimicry. Nature. 2011 Aug 14; 477(7363):203-6.
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Tn1546 is part of a larger plasmid-encoded genetic unit horizontally disseminated among clonal Enterococcus faecium lineages. J Antimicrob Chemother. 2010 Sep; 65(9):1894-906.
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A composite transposon associated with erythromycin and clindamycin resistance in group B Streptococcus. J Med Microbiol. 2007 Jul; 56(Pt 7):947-955.
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The search for a marsupial XIC reveals a break with vertebrate synteny. Chromosome Res. 2007; 15(2):137-46.
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Alternative end-joining in follicular lymphomas' t(14;18) translocation. Leukemia. 2002 Jan; 16(1):120-6.
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Mice with mutations in the mahogany gene Atrn have cerebral spongiform changes. J Neuropathol Exp Neurol. 2001 Jul; 60(7):724-30.
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Cloning of the Arabidopsis RSF1 gene by using a mapping strategy based on high-density DNA arrays and denaturing high-performance liquid chromatography. Plant Cell. 2000 Dec; 12(12):2485-2498.