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Chloramphenicol O-Acetyltransferase

"Chloramphenicol O-Acetyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.


This graph shows the total number of publications written about "Chloramphenicol O-Acetyltransferase" by people in Harvard Catalyst Profiles by year, and whether "Chloramphenicol O-Acetyltransferase" was a major or minor topic of these publication.
Bar chart showing 130 publications over 15 distinct years, with a maximum of 19 publications in 1993 and 1996
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.