Harvard Catalyst Profiles

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Caspases, Initiator

"Caspases, Initiator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

A subtype of caspases that contain long pro-domain regions that regulate the activation of the enzyme. The pro-domain regions contain protein-protein interaction motifs that can interact with specific signaling adaptor proteins such as DEATH DOMAIN RECEPTORS; DED SIGNALING ADAPTOR PROTEINS; and CARD SIGNALING ADAPTOR PROTEINS. Once activated, the initiator caspases can activate other caspases such as the EFFECTOR CASPASES.


This graph shows the total number of publications written about "Caspases, Initiator" by people in Harvard Catalyst Profiles by year, and whether "Caspases, Initiator" was a major or minor topic of these publication.
Bar chart showing 17 publications over 14 distinct years, with a maximum of 2 publications in 2016 and 2020 and 2021
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.