Casein Kinase Ialpha

"Casein Kinase Ialpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A casein kinase I isoenzyme that plays a role in intracellular signaling pathways including the WNT SIGNALING PATHWAY, the CELL CYCLE, membrane trafficking, and RNA processing. Multiple isoforms of casein kinase I alpha exist and are due to ALTERNATIVE SPLICING.

Descriptor ID

D048128

MeSH Number(s)

D05.500.117.750.100

D08.811.913.696.620.682.700.140.300.100

D12.776.476.081.750.100

D12.776.476.150.299.100

Concept/Terms

Casein Kinase Ialpha

Casein Kinase IalphaS

Casein Kinase IalphaLS

Casein Kinase IalphaL

Below are MeSH descriptors whose meaning is more general than "Casein Kinase Ialpha".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Casein Kinases [D08.811.913.696.620.682.700.140]
Casein Kinase I [D08.811.913.696.620.682.700.140.300]
Casein Kinase Ialpha [D08.811.913.696.620.682.700.140.300.100]

Below are MeSH descriptors whose meaning is related to "Casein Kinase Ialpha".

Below are MeSH descriptors whose meaning is more specific than "Casein Kinase Ialpha".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Casein Kinase Ialpha" by people in Harvard Catalyst Profiles by year, and whether "Casein Kinase Ialpha" was a major or minor topic of these publication.

Bar chart showing 15 publications over 10 distinct years, with a maximum of 3 publications in 2010 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	1	0	1
2010	3	0	3
2011	1	0	1
2013	0	1	1
2014	2	0	2
2016	1	0	1
2018	1	0	1
2019	1	0	1
2020	0	1	1
2021	3	0	3

Below are the most recent publications written about "Casein Kinase Ialpha" by people in Profiles.

Development of PDE6D and CK1a Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 01 13; 65(1):747-756.

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Reversible modulation of circadian time with chronophotopharmacology. Nat Commun. 2021 05 26; 12(1):3164.

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Reductive stability evaluation of 6-azopurine photoswitches for the regulation of CKIa activity and circadian rhythms. Org Biomol Chem. 2021 03 18; 19(10):2312-2321.

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Rapid and deep-scale ubiquitylation profiling for biology and translational research. Nat Commun. 2020 01 17; 11(1):359.

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Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome. Leukemia. 2019 07; 33(7):1759-1772.

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Potential biomarkers to detect traumatic brain injury by the profiling of salivary extracellular vesicles. J Cell Physiol. 2019 08; 234(8):14377-14388.

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Inhibition of Casein Kinase 1 Alpha in Acute Myeloid Leukemia. N Engl J Med. 2018 11 08; 379(19):1873-1874.

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CK1a suppresses lung tumour growth by stabilizing PTEN and inducing autophagy. Nat Cell Biol. 2018 04; 20(4):465-478.

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Structural basis of lenalidomide-induced CK1a degradation by the CRL4(CRBN) ubiquitin ligase. Nature. 2016 Apr 07; 532(7597):127-30.

View in: PubMed
CSNK1a1 mediates malignant plasma cell survival. Leukemia. 2015 Feb; 29(2):474-82.

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