Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)
"Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the formation of carbamoyl phosphate from ATP, carbon dioxide, and glutamine. This enzyme is important in the de novo biosynthesis of pyrimidines. EC 6.3.5.5.
Below are MeSH descriptors whose meaning is more general than "Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)".
Below are MeSH descriptors whose meaning is more specific than "Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)".
This graph shows the total number of publications written about "Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)" by people in Harvard Catalyst Profiles by year, and whether "Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2013 | 2 | 0 | 2 |
| 2018 | 1 | 1 | 2 |
| 2021 | 1 | 0 | 1 |
Below are the most recent publications written about "Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)" by people in Profiles.
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Uridine-responsive epileptic encephalopathy due to inherited variants in CAD: A Tale of Two Siblings. Ann Clin Transl Neurol. 2021 03; 8(3):716-722.
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Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures. Cell. 2018 09 06; 174(6):1559-1570.e22.
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The Sda and Cad glycan antigens and their glycosyltransferase, ß1,4GalNAcT-II, in xenotransplantation. Xenotransplantation. 2018 03; 25(2):e12386.
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Tracking a CAD-ALK gene rearrangement in urine and blood of a colorectal cancer patient treated with an ALK inhibitor. Ann Oncol. 2017 Jun 01; 28(6):1302-1308.
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Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis. Nature. 2015 Nov 19; 527(7578):379-383.
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Association of CAD, a multifunctional protein involved in pyrimidine synthesis, with mLST8, a component of the mTOR complexes. J Biomed Sci. 2013 Apr 18; 20:24.
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Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1. Science. 2013 Mar 15; 339(6125):1323-8.
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The nucleotide synthesis enzyme CAD inhibits NOD2 antibacterial function in human intestinal epithelial cells. Gastroenterology. 2012 Jun; 142(7):1483-92.e6.
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Protein kinase A phosphorylation of the multifunctional protein CAD antagonizes activation by the MAP kinase cascade. Mol Cell Biochem. 2007 Jul; 301(1-2):69-81.
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Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD. J Biol Chem. 2005 Jul 08; 280(27):25611-20.