COUP Transcription Factor II

"COUP Transcription Factor II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A COUP transcription factor that negatively regulates GENETIC TRANSCRIPTION and competes with other hormone receptors for the common response element AGGTCA. It can also stimulate transcription of genes involved in the metabolism of GLUCOSE and CHOLESTEROL.

Descriptor ID

D051837

MeSH Number(s)

D12.776.260.698.209.039.500

D12.776.260.703.200

D12.776.826.209.039.500

D12.776.930.669.209.039.500

D12.776.930.700.750

Concept/Terms

COUP Transcription Factor II

Below are MeSH descriptors whose meaning is more general than "COUP Transcription Factor II".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Receptors, Cytoplasmic and Nuclear [D12.776.260.698]
Orphan Nuclear Receptors [D12.776.260.698.209]
COUP Transcription Factors [D12.776.260.698.209.039]
COUP Transcription Factor II [D12.776.260.698.209.039.500]
Repressor Proteins [D12.776.260.703]
COUP Transcription Factor II [D12.776.260.703.200]
Receptors, Cytoplasmic and Nuclear [D12.776.826]
Orphan Nuclear Receptors [D12.776.826.209]
COUP Transcription Factors [D12.776.826.209.039]
COUP Transcription Factor II [D12.776.826.209.039.500]
Transcription Factors [D12.776.930]
Receptors, Cytoplasmic and Nuclear [D12.776.930.669]
Orphan Nuclear Receptors [D12.776.930.669.209]
COUP Transcription Factors [D12.776.930.669.209.039]
COUP Transcription Factor II [D12.776.930.669.209.039.500]
Repressor Proteins [D12.776.930.700]
COUP Transcription Factor II [D12.776.930.700.750]

Below are MeSH descriptors whose meaning is related to "COUP Transcription Factor II".

Below are MeSH descriptors whose meaning is more specific than "COUP Transcription Factor II".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "COUP Transcription Factor II" by people in Harvard Catalyst Profiles by year, and whether "COUP Transcription Factor II" was a major or minor topic of these publication.

Bar chart showing 8 publications over 8 distinct years, with a maximum of 1 publications in 2003 and 2008 and 2015 and 2016 and 2019 and 2020 and 2021 and 2023

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2008	1	0	1
2015	1	0	1
2016	1	0	1
2019	1	0	1
2020	1	0	1
2021	1	0	1
2023	0	1	1

Below are the most recent publications written about "COUP Transcription Factor II" by people in Profiles.

Heterozygous rare variants in NR2F2 cause a recognizable multiple congenital anomaly syndrome with developmental delays. Eur J Hum Genet. 2023 10; 31(10):1117-1124.

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Orphan nuclear receptor COUP-TFII enhances myofibroblast glycolysis leading to kidney fibrosis. EMBO Rep. 2021 06 04; 22(6):e51169.

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Regeneration of the pulmonary vascular endothelium after viral pneumonia requires COUP-TF2. Sci Adv. 2020 11; 6(48).

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A genome-wide association study implicates NR2F2 in lymphangioleiomyomatosis pathogenesis. Eur Respir J. 2019 06; 53(6).

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Essential role of prostaglandin E2 and the EP3 receptor in lymphatic vessel development during zebrafish embryogenesis. Sci Rep. 2019 05 21; 9(1):7650.

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Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis. Nat Commun. 2018 11 21; 9(1):4906.

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Single-cell analysis of early progenitor cells that build coronary arteries. Nature. 2018 07; 559(7714):356-362.

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De novo frameshift mutation in COUP-TFII (NR2F2) in human congenital diaphragmatic hernia. Am J Med Genet A. 2016 09; 170(9):2457-61.

View in: PubMed
Venous Endothelial Marker COUP-TFII Regulates the Distinct Pathologic Potentials of Adult Arteries and Veins. Sci Rep. 2015 Nov 05; 5:16193.

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Rare variants in NR2F2 cause congenital heart defects in humans. Am J Hum Genet. 2014 04 03; 94(4):574-85.

View in: PubMed

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