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CLOCK Proteins

"CLOCK Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.


This graph shows the total number of publications written about "CLOCK Proteins" by people in Harvard Catalyst Profiles by year, and whether "CLOCK Proteins" was a major or minor topic of these publication.
Bar chart showing 46 publications over 17 distinct years, with a maximum of 5 publications in 2007 and 2011 and 2013 and 2014
To see the data from this visualization as text, click here.
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