"C-Peptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.
MeSH Number(s)
D06.472.699.587.200.500.250
D12.644.548.586.200.500.250
Concept/Terms
C-Peptide- C-Peptide
- C Peptide
- Connecting Peptide
- Proinsulin C-Peptide
- Proinsulin C Peptide
- C-Peptide, Proinsulin
- C Peptide, Proinsulin
Below are MeSH descriptors whose meaning is more general than "C-Peptide".
Below are MeSH descriptors whose meaning is more specific than "C-Peptide".
This graph shows the total number of publications written about "C-Peptide" by people in Harvard Catalyst Profiles by year, and whether "C-Peptide" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 2 | 3 | 5 |
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 3 | 3 |
| 2001 | 1 | 8 | 9 |
| 2002 | 0 | 4 | 4 |
| 2003 | 1 | 10 | 11 |
| 2004 | 5 | 5 | 10 |
| 2005 | 5 | 6 | 11 |
| 2006 | 2 | 3 | 5 |
| 2007 | 2 | 6 | 8 |
| 2008 | 3 | 8 | 11 |
| 2009 | 5 | 2 | 7 |
| 2010 | 2 | 8 | 10 |
| 2011 | 4 | 8 | 12 |
| 2012 | 5 | 7 | 12 |
| 2013 | 1 | 3 | 4 |
| 2014 | 2 | 6 | 8 |
| 2015 | 3 | 3 | 6 |
| 2016 | 1 | 11 | 12 |
| 2017 | 1 | 4 | 5 |
| 2018 | 2 | 8 | 10 |
| 2019 | 2 | 5 | 7 |
| 2020 | 1 | 5 | 6 |
| 2021 | 0 | 4 | 4 |
| 2022 | 0 | 7 | 7 |
| 2023 | 0 | 2 | 2 |
Below are the most recent publications written about "C-Peptide" by people in Profiles.
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Loss of Visceral Fat is Associated with a Reduction in Inflammatory Status in Patients with Metabolic Syndrome. Mol Nutr Food Res. 2023 02; 67(4):e2200264.
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Fructose consumption from different food sources and cardiometabolic biomarkers: cross-sectional associations in US men and women. Am J Clin Nutr. 2023 Mar; 117(3):490-498.
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Habitual coffee consumption and subsequent risk of type 2 diabetes in individuals with a history of gestational diabetes - a prospective study. Am J Clin Nutr. 2022 12 19; 116(6):1693-1703.
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The course of C-peptide levels in patients developing diabetes during anti-PD-1 therapy. Biomed Pharmacother. 2022 Dec; 156:113839.
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Outcomes Following Extrahepatic and Intraportal Pancreatic Islet Transplantation: A Comparative Cohort Study. Transplantation. 2022 11 01; 106(11):2224-2231.
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Association of animal and plant protein intakes with biomarkers of insulin and insulin-like growth factor axis. Clin Nutr. 2022 06; 41(6):1272-1280.
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Methods paper: Performance characteristics of novel assays for circulating levels of proglucagon-derived peptides and validation in a placebo controlled cross-over randomized clinical trial. Metabolism. 2022 04; 129:155157.
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Insulin regulates arginine-stimulated insulin secretion in humans. Metabolism. 2022 03; 128:155117.
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Skeletal status in children and adolescents with new-onset type 1 diabetes: a preliminary study based on bone densitometry and quantitative ultrasound. Pediatr Endocrinol Diabetes Metab. 2022; 28(3):197-206.
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Disordered glycemic control in women with type 2 diabetes is associated with increased TNF receptor-2 levels. J Diabetes Complications. 2021 09; 35(9):107974.