"Auranofin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An oral chrysotherapeutic agent for the treatment of rheumatoid arthritis. Its exact mechanism of action is unknown, but it is believed to act via immunological mechanisms and alteration of lysosomal enzyme activity. Its efficacy is slightly less than that of injected gold salts, but it is better tolerated, and side effects which occur are potentially less serious.
Concept/Terms
Ridauran- Ridauran
- Robapharm Brand of Auranofin
- Auranofin Robapharm Brand
Crisinor- Crisinor
- Rubio Brand of Auranofin
- Auranofin Rubio Brand
Ridaura- Ridaura
- SmithKline Beecham Brand of Auranofin
- Recordati Brand of Auranofin
- Auranofin Recordati Brand
- Yamanouchi Brand of Auranofin
- Auranofin Yamanouchi Brand
Below are MeSH descriptors whose meaning is more general than "Auranofin".
Below are MeSH descriptors whose meaning is more specific than "Auranofin".
This graph shows the total number of publications written about "Auranofin" by people in Harvard Catalyst Profiles by year, and whether "Auranofin" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1999 | 1 | 1 | 2 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
Below are the most recent publications written about "Auranofin" by people in Profiles.
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In Vitro Activity of Auranofin in Combination With Aztreonam-Avibactam Against Metallo-ß-lactamase (MBL)-Producing Enterobacterales. Front Cell Infect Microbiol. 2021; 11:755763.
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The efficacy of a coordinated pharmacological blockade in glioblastoma stem cells with nine repurposed drugs using the CUSP9 strategy. J Cancer Res Clin Oncol. 2019 Jun; 145(6):1495-1507.
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Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia. Cancer Res. 2014 May 01; 74(9):2520-32.
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The gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and inhibition of NF-?B activity. Leuk Res. 2011 Feb; 35(2):243-9.
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Mitochondrial respiratory chain involvement in peroxiredoxin 3 oxidation by phenethyl isothiocyanate and auranofin. FEBS Lett. 2010 Mar 19; 584(6):1257-62.
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Regulation of interleukin-4 signaling by extracellular reduction of intramolecular disulfides. Biochem Biophys Res Commun. 2009 Dec 25; 390(4):1272-7.
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The selenoproteome is dispensable in bloodstream forms of Trypanosoma brucei. Mol Biochem Parasitol. 2009 Dec; 168(2):191-3.
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The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation. Biochem Pharmacol. 2008 Oct 30; 76(9):1097-109.
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Identifying and characterizing the biological targets of metallotherapeutics: Two approaches using Au(I)-protein interactions as model systems. Anal Biochem. 2008 Nov 01; 382(1):63-5.
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Regulated protein denitrosylation by cytosolic and mitochondrial thioredoxins. Science. 2008 May 23; 320(5879):1050-4.