Harvard Catalyst Profiles

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Apoptosis Inducing Factor

"Apoptosis Inducing Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.


This graph shows the total number of publications written about "Apoptosis Inducing Factor" by people in Harvard Catalyst Profiles by year, and whether "Apoptosis Inducing Factor" was a major or minor topic of these publication.
Bar chart showing 36 publications over 15 distinct years, with a maximum of 5 publications in 2004 and 2010
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.