Harvard Catalyst Profiles

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Apoptosis Inducing Factor

"Apoptosis Inducing Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.


This graph shows the total number of publications written about "Apoptosis Inducing Factor" by people in Harvard Catalyst Profiles by year, and whether "Apoptosis Inducing Factor" was a major or minor topic of these publication.
Bar chart showing 38 publications over 18 distinct years, with a maximum of 5 publications in 2004 and 2010
To see the data from this visualization as text, click here.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.