"Apoptosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Concept/Terms
Apoptosis- Apoptosis
- Programmed Cell Death, Type I
Below are MeSH descriptors whose meaning is more general than "Apoptosis".
Below are MeSH descriptors whose meaning is more specific than "Apoptosis".
This graph shows the total number of publications written about "Apoptosis" by people in Harvard Catalyst Profiles by year, and whether "Apoptosis" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 5 | 6 | 11 |
| 1994 | 15 | 7 | 22 |
| 1995 | 27 | 21 | 48 |
| 1996 | 45 | 27 | 72 |
| 1997 | 76 | 36 | 112 |
| 1998 | 77 | 67 | 144 |
| 1999 | 103 | 74 | 177 |
| 2000 | 102 | 83 | 185 |
| 2001 | 84 | 100 | 184 |
| 2002 | 111 | 137 | 248 |
| 2003 | 100 | 154 | 254 |
| 2004 | 113 | 153 | 266 |
| 2005 | 115 | 184 | 299 |
| 2006 | 116 | 172 | 288 |
| 2007 | 95 | 159 | 254 |
| 2008 | 107 | 163 | 270 |
| 2009 | 97 | 172 | 269 |
| 2010 | 94 | 176 | 270 |
| 2011 | 88 | 229 | 317 |
| 2012 | 83 | 196 | 279 |
| 2013 | 90 | 228 | 318 |
| 2014 | 78 | 222 | 300 |
| 2015 | 60 | 217 | 277 |
| 2016 | 69 | 200 | 269 |
| 2017 | 59 | 233 | 292 |
| 2018 | 54 | 168 | 222 |
| 2019 | 54 | 186 | 240 |
| 2020 | 47 | 175 | 222 |
| 2021 | 33 | 136 | 169 |
| 2022 | 11 | 61 | 72 |
| 2023 | 1 | 0 | 1 |
Below are the most recent publications written about "Apoptosis" by people in Profiles.
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Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis. Nat Commun. 2023 Jan 04; 14(1):57.
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Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia. Cancer Cell. 2023 Jan 09; 41(1):164-180.e8.
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Lisaftoclax (APG-2575) Is a Novel BCL-2 Inhibitor with Robust Antitumor Activity in Preclinical Models of Hematologic Malignancy. Clin Cancer Res. 2022 12 15; 28(24):5455-5468.
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A novel 4'-brominated derivative of fisetin induces cell cycle arrest and apoptosis and inhibits EGFR/ERK1/2/STAT3 pathways in non-small-cell lung cancer without any adverse effects in mice. FASEB J. 2022 12; 36(12):e22654.
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Cyclin G1 induces maladaptive proximal tubule cell dedifferentiation and renal fibrosis through CDK5 activation. J Clin Invest. 2022 12 01; 132(23).
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X-linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL. EMBO Mol Med. 2023 01 11; 15(1):e14557.
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CD11c regulates late-stage T cell development in the thymus. Front Immunol. 2022; 13:1040818.
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The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma. Nat Commun. 2022 11 10; 13(1):6820.
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Sustained Supratherapeutic Paclitaxel Delivery Enhances Irreversible Sarcoma Cell Death. Mol Cancer Ther. 2022 11 03; 21(11):1663-1673.
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A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Antiapoptotic Protein in Kidney Cancer. Clin Cancer Res. 2022 11 01; 28(21):4689-4701.