"Apoptosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Concept/Terms
Apoptosis- Apoptosis
- Programmed Cell Death, Type I
Below are MeSH descriptors whose meaning is more general than "Apoptosis".
Below are MeSH descriptors whose meaning is more specific than "Apoptosis".
This graph shows the total number of publications written about "Apoptosis" by people in Harvard Catalyst Profiles by year, and whether "Apoptosis" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 1 | 1 | 2 |
| 1993 | 5 | 6 | 11 |
| 1994 | 15 | 7 | 22 |
| 1995 | 28 | 21 | 49 |
| 1996 | 45 | 29 | 74 |
| 1997 | 78 | 37 | 115 |
| 1998 | 78 | 70 | 148 |
| 1999 | 106 | 79 | 185 |
| 2000 | 106 | 88 | 194 |
| 2001 | 92 | 108 | 200 |
| 2002 | 116 | 144 | 260 |
| 2003 | 109 | 162 | 271 |
| 2004 | 115 | 155 | 270 |
| 2005 | 117 | 196 | 313 |
| 2006 | 118 | 179 | 297 |
| 2007 | 108 | 164 | 272 |
| 2008 | 110 | 167 | 277 |
| 2009 | 109 | 181 | 290 |
| 2010 | 98 | 181 | 279 |
| 2011 | 90 | 242 | 332 |
| 2012 | 91 | 206 | 297 |
| 2013 | 99 | 246 | 345 |
| 2014 | 84 | 240 | 324 |
| 2015 | 64 | 229 | 293 |
| 2016 | 75 | 226 | 301 |
| 2017 | 61 | 237 | 298 |
| 2018 | 51 | 174 | 225 |
| 2019 | 52 | 188 | 240 |
| 2020 | 36 | 155 | 191 |
| 2021 | 9 | 28 | 37 |
Below are the most recent publications written about "Apoptosis" by people in Profiles.
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The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core. Nat Commun. 2021 08 13; 12(1):4932.
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Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy. Nat Commun. 2021 08 06; 12(1):4777.
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Hypoxia Enhances the Expression of RNASET2 in Human Monocyte-Derived Dendritic Cells: Role of PI3K/AKT Pathway. Int J Mol Sci. 2021 Jul 15; 22(14).
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Peripheral Opioid Receptor Blockade Enhances Epithelial Damage in Piroxicam-Accelerated Colitis in IL-10-Deficient Mice. Int J Mol Sci. 2021 Jul 09; 22(14).
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Iron-dependent apoptosis causes embryotoxicity in inflamed and obese pregnancy. Nat Commun. 2021 06 29; 12(1):4026.
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Toxicogenicity and mechanistic pathways of aflatoxin B1 induced renal injury. Environ Toxicol. 2021 Sep; 36(9):1857-1872.
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Integrated genomics and comprehensive validation reveal drivers of genomic evolution in esophageal adenocarcinoma. Commun Biol. 2021 05 24; 4(1):617.
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TNF controls a speed-accuracy tradeoff in the cell death decision to restrict viral spread. Nat Commun. 2021 05 20; 12(1):2992.
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Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo. Nat Chem Biol. 2021 09; 17(9):954-963.
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HtrA serine proteases in cancers: A target of interest for cancer therapy. Biomed Pharmacother. 2021 Jul; 139:111603.