Harvard Catalyst Profiles

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Antibody-Dependent Cell Cytotoxicity

"Antibody-Dependent Cell Cytotoxicity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN G whose Fc portion is intact. The effector cell is a "killer" cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.


This graph shows the total number of publications written about "Antibody-Dependent Cell Cytotoxicity" by people in Harvard Catalyst Profiles by year, and whether "Antibody-Dependent Cell Cytotoxicity" was a major or minor topic of these publication.
Bar chart showing 135 publications over 29 distinct years, with a maximum of 13 publications in 2016
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.