"Amiloride" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
Concept/Terms
Kaluril- Kaluril
- Alphapharm Brand of Amiloride Hydrochloride
Midamor- Midamor
- Modamide
- Merck Sharp & Dohme Brand of Amiloride Hydrochloride
- Cahill May Roberts Brand of Amiloride Hydrochloride
- Merck Brand of Amiloride Hydrochloride
Amiloberag- Amiloberag
- Berolina Brand of Amiloride Hydrochloride
Amidal- Amidal
- Douglas Brand of Amiloride Hydrochloride
Amiduret Trom- Amiduret Trom
- Trom, Amiduret
- Trommsdorff Brand of Amiloride Hydrochloride
Midoride- Midoride
- Amrad Brand of Amiloride Hydrochloride
Below are MeSH descriptors whose meaning is more general than "Amiloride".
Below are MeSH descriptors whose meaning is more specific than "Amiloride".
This graph shows the total number of publications written about "Amiloride" by people in Harvard Catalyst Profiles by year, and whether "Amiloride" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 4 | 4 |
| 1995 | 0 | 6 | 6 |
| 1996 | 1 | 3 | 4 |
| 1997 | 0 | 3 | 3 |
| 1998 | 3 | 2 | 5 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2001 | 1 | 3 | 4 |
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 3 | 4 |
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 1 | 2 |
| 2013 | 0 | 4 | 4 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 2 | 2 |
| 2016 | 0 | 1 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 2 | 3 |
Below are the most recent publications written about "Amiloride" by people in Profiles.
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Evaluating the clinical and mechanistic effects of eplerenone and amiloride monotherapy, and combination therapy with cinacalcet, in primary hyperparathyroidism: A placebo-controlled randomized trial. Clin Endocrinol (Oxf). 2023 04; 98(4):516-526.
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TCL-318 Evaluation of the Antitumor Activity of Amiloride in Peripheral T-Cell Lymphomas Using In-Vitro Models. Clin Lymphoma Myeloma Leuk. 2022 Oct; 22 Suppl 2:S399.
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An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis. Commun Biol. 2022 02 24; 5(1):166.
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Blocking NHE Channels Reduces the Ability of In Vitro Capacitated Mammalian Sperm to Respond to Progesterone Stimulus. Int J Mol Sci. 2021 Nov 23; 22(23).
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Vps34-mediated macropinocytosis in Tuberous Sclerosis Complex 2-deficient cells supports tumorigenesis. Sci Rep. 2018 09 21; 8(1):14161.
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Urinary concentrations of 3-(diethylcarbamoyl)benzoic acid (DCBA), a major metabolite of N,N-diethyl-m-toluamide (DEET) and semen parameters among men attending a fertility center. Hum Reprod. 2017 Dec 01; 32(12):2532-2539.
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Amiloride, An Old Diuretic Drug, Is a Potential Therapeutic Agent for Multiple Myeloma. Clin Cancer Res. 2017 Nov 01; 23(21):6602-6615.
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Renal apnoea: extreme disturbance of homoeostasis in a child with Bartter syndrome type IV. Lancet. 2016 Aug 06; 388(10044):631-2.
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Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride. Protein Cell. 2016 Apr; 7(4):300-304.
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Combination therapy with cystic fibrosis transmembrane conductance regulator modulators augment the airway functional microanatomy. Am J Physiol Lung Cell Mol Physiol. 2016 05 15; 310(10):L928-39.