"Amiloride" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
Concept/Terms
Kaluril- Kaluril
- Alphapharm Brand of Amiloride Hydrochloride
Midamor- Midamor
- Modamide
- Merck Sharp & Dohme Brand of Amiloride Hydrochloride
- Cahill May Roberts Brand of Amiloride Hydrochloride
- Merck Brand of Amiloride Hydrochloride
Amiloberag- Amiloberag
- Berolina Brand of Amiloride Hydrochloride
Amidal- Amidal
- Douglas Brand of Amiloride Hydrochloride
Amiduret Trom- Amiduret Trom
- Trom, Amiduret
- Trommsdorff Brand of Amiloride Hydrochloride
Midoride- Midoride
- Amrad Brand of Amiloride Hydrochloride
Below are MeSH descriptors whose meaning is more general than "Amiloride".
Below are MeSH descriptors whose meaning is more specific than "Amiloride".
This graph shows the total number of publications written about "Amiloride" by people in Harvard Catalyst Profiles by year, and whether "Amiloride" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 1 | 5 | 6 |
| 1992 | 0 | 4 | 4 |
| 1993 | 0 | 2 | 2 |
| 1994 | 0 | 4 | 4 |
| 1995 | 0 | 7 | 7 |
| 1996 | 1 | 3 | 4 |
| 1997 | 0 | 4 | 4 |
| 1998 | 3 | 3 | 6 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 3 | 3 |
| 2001 | 1 | 3 | 4 |
| 2002 | 1 | 1 | 2 |
| 2003 | 1 | 3 | 4 |
| 2004 | 1 | 1 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 2 | 3 |
| 2013 | 0 | 3 | 3 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
Below are the most recent publications written about "Amiloride" by people in Profiles.
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Vps34-mediated macropinocytosis in Tuberous Sclerosis Complex 2-deficient cells supports tumorigenesis. Sci Rep. 2018 09 21; 8(1):14161.
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Urinary concentrations of 3-(diethylcarbamoyl)benzoic acid (DCBA), a major metabolite of N,N-diethyl-m-toluamide (DEET) and semen parameters among men attending a fertility center. Hum Reprod. 2017 Dec 01; 32(12):2532-2539.
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Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride. Protein Cell. 2016 Apr; 7(4):300-304.
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Combination therapy with cystic fibrosis transmembrane conductance regulator modulators augment the airway functional microanatomy. . 2016 05 15; 310(10):L928-39.
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Increased Epithelial Sodium Channel Activity Contributes to Hypertension Caused by Na+-HCO3- Cotransporter Electrogenic 2 Deficiency. Hypertension. 2015 Jul; 66(1):68-74.
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Inhibition of RANKL-dependent cellular fusion in pre-osteoclasts by amiloride and a NHE10-specific monoclonal antibody. Cell Biol Int. 2015 Jun; 39(6):696-709.
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Relation between BK-a/ß4-mediated potassium secretion and ENaC-mediated sodium reabsorption. Kidney Int. 2014 Jul; 86(1):139-45.
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Activation of virus uptake through induction of macropinocytosis with a novel polymerizing peptide. FASEB J. 2014 Jan; 28(1):106-16.
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A presynaptic ENaC channel drives homeostatic plasticity. Neuron. 2013 Sep 18; 79(6):1183-96.
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Novel small molecule epithelial sodium channel inhibitors as potential therapeutics in cystic fibrosis - a patent evaluation. Expert Opin Ther Pat. 2013 Oct; 23(10):1383-9.