Harvard Catalyst Profiles

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Alternative Splicing

"Alternative Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.


This graph shows the total number of publications written about "Alternative Splicing" by people in Harvard Catalyst Profiles by year, and whether "Alternative Splicing" was a major or minor topic of these publication.
Bar chart showing 763 publications over 29 distinct years, with a maximum of 39 publications in 2014
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.