Aldehyde-Lyases

"Aldehyde-Lyases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Enzymes that catalyze a reverse aldol condensation. A molecule containing a hydroxyl group and a carbonyl group is cleaved at a C-C bond to produce two smaller molecules (ALDEHYDES or KETONES). EC 4.1.2.

Descriptor ID

D000446

MeSH Number(s)

D08.811.520.224.062

Concept/Terms

Aldehyde-Lyases

Below are MeSH descriptors whose meaning is more general than "Aldehyde-Lyases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Lyases [D08.811.520]
Carbon-Carbon Lyases [D08.811.520.224]
Aldehyde-Lyases [D08.811.520.224.062]

Below are MeSH descriptors whose meaning is related to "Aldehyde-Lyases".

Below are MeSH descriptors whose meaning is more specific than "Aldehyde-Lyases".

Aldehyde-Lyases
Fructose-Bisphosphate Aldolase

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Aldehyde-Lyases" by people in Harvard Catalyst Profiles by year, and whether "Aldehyde-Lyases" was a major or minor topic of these publication.

Bar chart showing 11 publications over 8 distinct years, with a maximum of 3 publications in 2008

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2005	1	0	1
2008	1	2	3
2009	0	1	1
2010	1	0	1
2017	2	0	2
2020	1	0	1
2022	0	1	1

Below are the most recent publications written about "Aldehyde-Lyases" by people in Profiles.

ER Stress-Induced Sphingosine-1-Phosphate Lyase Phosphorylation Potentiates the Mitochondrial Unfolded Protein Response. J Lipid Res. 2022 10; 63(10):100279.

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Responsiveness of sphingosine phosphate lyase insufficiency syndrome to vitamin B6 cofactor supplementation. J Inherit Metab Dis. 2020 09; 43(5):1131-1142.

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Tunable Nanoscale Cages from Self-Assembling DNA and Protein Building Blocks. ACS Nano. 2019 03 26; 13(3):3545-3554.

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Identifying therapeutic targets by combining transcriptional data with ordinal clinical measurements. Nat Commun. 2017 09 20; 8(1):623.

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Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency. J Clin Invest. 2017 Mar 01; 127(3):912-928.

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Response of methicillin-resistant Staphylococcus aureus to amicoumacin A. PLoS One. 2012; 7(3):e34037.

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Observation of a chemically labile, noncovalent enzyme intermediate in the reaction of metal-dependent Aquifex pyrophilus KDO8PS by time-resolved mass spectrometry. Rapid Commun Mass Spectrom. 2010 Jul 15; 24(13):1919-24.

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Active-site engineering of benzaldehyde lyase shows that a point mutation can confer both new reactivity and susceptibility to mechanism-based inhibition. J Am Chem Soc. 2010 Jan 20; 132(2):438-9.

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Snapshot of a reaction intermediate: analysis of benzoylformate decarboxylase in complex with a benzoylphosphonate inhibitor. Biochemistry. 2009 Apr 21; 48(15):3247-57.

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Probing the active center of benzaldehyde lyase with substitutions and the pseudosubstrate analogue benzoylphosphonic acid methyl ester. Biochemistry. 2008 Jul 22; 47(29):7734-43.

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