"Adjuvants, Immunologic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Concept/Terms
Adjuvants, Immunologic- Adjuvants, Immunologic
- Adjuvants, Immunological
- Immunological Adjuvants
- Immunological Adjuvant
- Adjuvant, Immunological
- Adjuvant, Immunologic
- Immunologic Adjuvant
- Immunopotentiators
- Immunoactivators
- Immunoadjuvants
- Immunostimulants
- Immunologic Adjuvants
Below are MeSH descriptors whose meaning is more general than "Adjuvants, Immunologic".
Below are MeSH descriptors whose meaning is more specific than "Adjuvants, Immunologic".
This graph shows the total number of publications written about "Adjuvants, Immunologic" by people in Harvard Catalyst Profiles by year, and whether "Adjuvants, Immunologic" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 5 | 5 |
| 1994 | 5 | 2 | 7 |
| 1995 | 3 | 6 | 9 |
| 1996 | 6 | 1 | 7 |
| 1997 | 11 | 5 | 16 |
| 1998 | 7 | 5 | 12 |
| 1999 | 9 | 9 | 18 |
| 2000 | 10 | 8 | 18 |
| 2001 | 10 | 14 | 24 |
| 2002 | 19 | 10 | 29 |
| 2003 | 22 | 17 | 39 |
| 2004 | 17 | 6 | 23 |
| 2005 | 12 | 11 | 23 |
| 2006 | 14 | 8 | 22 |
| 2007 | 10 | 6 | 16 |
| 2008 | 10 | 13 | 23 |
| 2009 | 4 | 13 | 17 |
| 2010 | 7 | 6 | 13 |
| 2011 | 8 | 8 | 16 |
| 2012 | 11 | 14 | 25 |
| 2013 | 8 | 11 | 19 |
| 2014 | 8 | 12 | 20 |
| 2015 | 15 | 9 | 24 |
| 2016 | 12 | 11 | 23 |
| 2017 | 9 | 11 | 20 |
| 2018 | 9 | 5 | 14 |
| 2019 | 7 | 15 | 22 |
| 2020 | 14 | 14 | 28 |
| 2021 | 12 | 11 | 23 |
| 2022 | 2 | 31 | 33 |
Below are the most recent publications written about "Adjuvants, Immunologic" by people in Profiles.
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A Phase 1/2 Study of a Respiratory Syncytial Virus Prefusion F Vaccine With and Without Adjuvant in Healthy Older Adults. J Infect Dis. 2022 12 13; 226(12):2054-2063.
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A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity. Emerg Microbes Infect. 2022 Dec; 11(1):914-925.
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Longitudinal utilization of systemic immunomodulators before and after dupilumab approval in children with atopic dermatitis. Pediatr Dermatol. 2023 Jan; 40(1):132-134.
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1270 nm near-infrared light as a novel vaccine adjuvant acts on mitochondrial photoreception in intradermal vaccines. Front Immunol. 2022; 13:1028733.
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Efficacy of mucosal vaccination using a protozoan parasite as a vehicle for antigen delivery: IgG and neutralizing response after rectal administration of LeCoVax-2, a candidate vaccine against COVID-19. Pharmacol Res. 2022 12; 186:106546.
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Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination. Nat Immunol. 2022 12; 23(12):1777-1787.
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An Oil-in-Water adjuvant significantly increased influenza A/H7N9 split virus Vaccine-Induced circulating follicular helper T (cTFH) cells and antibody responses. Vaccine. 2022 Nov 22; 40(49):7065-7072.
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Development of a TLR7/8 agonist adjuvant formulation to overcome early life hyporesponsiveness to DTaP vaccination. Sci Rep. 2022 10 18; 12(1):16860.
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A randomised phase II trial of a trivalent ganglioside vaccine targeting GM2, GD2 and GD3 combined with immunological adjuvant OPT-821 versus OPT-821 alone in metastatic sarcoma patients rendered disease-free by surgery. Eur J Cancer. 2022 11; 176:155-163.
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Inherited Germline Cancer Susceptibility Gene Variants in Individuals with Non-Muscle-Invasive Bladder Cancer. Clin Cancer Res. 2022 10 03; 28(19):4267-4277.