Actins

"Actins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.

Descriptor ID

D000199

MeSH Number(s)

D05.750.078.730.250

D12.776.210.500.100

D12.776.220.525.255

Concept/Terms

Below are MeSH descriptors whose meaning is more general than "Actins".

Chemicals and Drugs [D]
Macromolecular Substances [D05]
Polymers [D05.750]
Biopolymers [D05.750.078]
Microfilament Proteins [D05.750.078.730]
Actins [D05.750.078.730.250]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Contractile Proteins [D12.776.210]
Muscle Proteins [D12.776.210.500]
Actins [D12.776.210.500.100]
Cytoskeletal Proteins [D12.776.220]
Microfilament Proteins [D12.776.220.525]
Actins [D12.776.220.525.255]

Below are MeSH descriptors whose meaning is more specific than "Actins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Actins" by people in Harvard Catalyst Profiles by year, and whether "Actins" was a major or minor topic of these publication.

Bar chart showing 1430 publications over 31 distinct years, with a maximum of 77 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	11	26	37
1994	6	19	25
1995	22	21	43
1996	7	23	30
1997	21	32	53
1998	14	29	43
1999	27	33	60
2000	27	39	66
2001	28	34	62
2002	24	25	49
2003	18	33	51
2004	26	51	77
2005	22	47	69
2006	21	36	57
2007	21	36	57
2008	21	29	50
2009	18	40	58
2010	24	31	55
2011	19	40	59
2012	16	32	48
2013	17	28	45
2014	15	27	42
2015	13	35	48
2016	10	25	35
2017	16	19	35
2018	18	20	38
2019	15	25	40
2020	15	14	29
2021	15	12	27
2022	12	16	28
2023	7	7	14

Below are the most recent publications written about "Actins" by people in Profiles.

PLS3 missense variants affecting the actin-binding domains cause X-linked congenital diaphragmatic hernia and body-wall defects. Am J Hum Genet. 2023 10 05; 110(10):1787-1803.

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Sensing their plasma membrane curvature allows migrating cells to circumvent obstacles. Nat Commun. 2023 09 13; 14(1):5644.

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Preclinical characterization of the efficacy and safety of biologic N-001 as a novel pain analgesic for post-operative acute pain treatment. Sci Rep. 2023 07 21; 13(1):11778.

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De novo missense variants in phosphatidylinositol kinase PIP5KI? underlie a neurodevelopmental syndrome associated with altered phosphoinositide signaling. Am J Hum Genet. 2023 08 03; 110(8):1377-1393.

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Branched-chain actin dynamics polarizes vesicle trajectories and partitions apicobasal epithelial membrane domains. Sci Adv. 2023 06 28; 9(26):eade4022.

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Inherited ARPC5 mutations cause an actinopathy impairing cell motility and disrupting cytokine signaling. Nat Commun. 2023 Jun 22; 14(1):3708.

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A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes. Nat Metab. 2023 05; 5(5):861-879.

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Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis. Nat Commun. 2023 05 20; 14(1):2888.

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ARPC5 isoforms and their regulation by calcium-calmodulin-N-WASP drive distinct Arp2/3-dependent actin remodeling events in CD4 T cells. Elife. 2023 05 10; 12.

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DANGER Signals Activate G -Protein Receptor Kinases Suppressing Neutrophil Function and Predisposing to Infection After Tissue Trauma. Ann Surg. 2023 12 01; 278(6):e1277-e1288.

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