"Acetyl-CoA Carboxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A carboxylating enzyme that catalyzes the conversion of ATP, acetyl-CoA, and HCO3- to ADP, orthophosphate, and malonyl-CoA. It is a biotinyl-protein that also catalyzes transcarboxylation. The plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA (From Enzyme Nomenclature, 1992) EC 6.4.1.2.
Concept/Terms
Acetyl-CoA Carboxylase- Acetyl-CoA Carboxylase
- Acetyl CoA Carboxylase
- Carboxylase, Acetyl-CoA
- Acetyl Coenzyme A Carboxylase
Below are MeSH descriptors whose meaning is more general than "Acetyl-CoA Carboxylase".
Below are MeSH descriptors whose meaning is more specific than "Acetyl-CoA Carboxylase".
This graph shows the total number of publications written about "Acetyl-CoA Carboxylase" by people in Harvard Catalyst Profiles by year, and whether "Acetyl-CoA Carboxylase" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 2 | 1 | 3 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 0 | 4 | 4 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 2 | 2 | 4 |
| 2007 | 1 | 2 | 3 |
| 2008 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 3 | 4 |
| 2012 | 0 | 4 | 4 |
| 2013 | 0 | 3 | 3 |
| 2014 | 0 | 2 | 2 |
| 2016 | 3 | 0 | 3 |
| 2018 | 4 | 0 | 4 |
| 2019 | 0 | 2 | 2 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 1 | 2 |
Below are the most recent publications written about "Acetyl-CoA Carboxylase" by people in Profiles.
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Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer. Cell Rep Med. 2021 12 21; 2(12):100471.
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Fine-Tuning Lipid Metabolism by Targeting Mitochondria-Associated Acetyl-CoA-Carboxylase 2 in BRAFV600E Papillary Thyroid Carcinoma. Thyroid. 2021 09; 31(9):1335-1358.
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PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle. Cell Metab. 2020 08 04; 32(2):215-228.e7.
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Metformin prevents the pathological browning of subcutaneous white adipose tissue. Mol Metab. 2019 11; 29:12-23.
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Elevated O-GlcNAcylation enhances pro-inflammatory Th17 function by altering the intracellular lipid microenvironment. J Biol Chem. 2019 05 31; 294(22):8973-8990.
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Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma. Cell Metab. 2019 01 08; 29(1):174-182.e5.
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Circulating Biomarkers From the Phase 1 Trial of Sirolimus and Autophagy Inhibition for Patients With Lymphangioleiomyomatosis. Chest. 2018 11; 154(5):1070-1082.
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Structural basis for regulation of human acetyl-CoA carboxylase. Nature. 2018 06; 558(7710):470-474.
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Fatty Acid Synthase and Acetyl-CoA Carboxylase Are Expressed in Nodal Metastatic Melanoma But Not in Benign Intracapsular Nodal Nevi. Am J Dermatopathol. 2018 Apr; 40(4):259-264.
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PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2. Mol Cell. 2016 09 15; 63(6):1006-20.