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2',5'-Oligoadenylate Synthetase

"2',5'-Oligoadenylate Synthetase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions. EC 2.7.7.-.


This graph shows the total number of publications written about "2',5'-Oligoadenylate Synthetase" by people in Harvard Catalyst Profiles by year, and whether "2',5'-Oligoadenylate Synthetase" was a major or minor topic of these publication.
Bar chart showing 14 publications over 8 distinct years, with a maximum of 3 publications in 2010 and 2013
To see the data from this visualization as text, click here.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.