12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
"12-Hydroxy-5,8,10,14-eicosatetraenoic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)
MeSH Number(s)
D10.251.355.096.450.425
D10.251.355.255.100.300.425
Concept/Terms
12-S-HETE- 12-S-HETE
- 12-S-Hydroxyeicosatetraenoic Acid
- 12 S Hydroxyeicosatetraenoic Acid
- Acid, 12-S-Hydroxyeicosatetraenoic
Below are MeSH descriptors whose meaning is more general than "12-Hydroxy-5,8,10,14-eicosatetraenoic Acid".
Below are MeSH descriptors whose meaning is more specific than "12-Hydroxy-5,8,10,14-eicosatetraenoic Acid".
This graph shows the total number of publications written about "12-Hydroxy-5,8,10,14-eicosatetraenoic Acid" by people in Harvard Catalyst Profiles by year, and whether "12-Hydroxy-5,8,10,14-eicosatetraenoic Acid" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
Below are the most recent publications written about "12-Hydroxy-5,8,10,14-eicosatetraenoic Acid" by people in Profiles.
-
Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy. Diabetologia. 2018 05; 61(5):1220-1232.
-
Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling. FASEB J. 2013 Feb; 27(2):437-45.
-
Impaired phagocytosis in localized aggressive periodontitis: rescue by Resolvin E1. PLoS One. 2011; 6(9):e24422.
-
Selective eicosanoid-generating capacity of cytoplasmic phospholipase A2 in Pseudomonas aeruginosa-infected epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011 Feb; 300(2):L286-94.
-
Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI). J Immunol. 2009 Oct 01; 183(7):4715-22.
-
Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells. J Biol Chem. 2006 Jul 07; 281(27):18601-9.
-
Impaired arachidonic acid-mediated dilation of small mesenteric arteries in Zucker diabetic fatty rats. Am J Physiol Heart Circ Physiol. 2005 May; 288(5):H2210-8.
-
12-lipoxygenase metabolites of arachidonic acid mediate metabotropic glutamate receptor-dependent long-term depression at hippocampal CA3-CA1 synapses. J Neurosci. 2003 Dec 10; 23(36):11427-35.
-
Platelet-type 12-lipoxygenase activates NF-kappaB in prostate cancer cells. Prostaglandins Other Lipid Mediat. 2003 Jul; 71(3-4):189-204.
-
Growth factor-induced proliferation in corneal epithelial cells is mediated by 12(S)-HETE. Exp Eye Res. 2003 May; 76(5):613-22.