Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

1-Methyl-4-phenylpyridinium

"1-Methyl-4-phenylpyridinium" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.


This graph shows the total number of publications written about "1-Methyl-4-phenylpyridinium" by people in Harvard Catalyst Profiles by year, and whether "1-Methyl-4-phenylpyridinium" was a major or minor topic of these publication.
Bar chart showing 26 publications over 16 distinct years, with a maximum of 3 publications in 1996 and 2004
To see the data from this visualization as text, click here.
Related Networks
People
Explore
_
Similar Concepts
_
Top Journals 
_
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.