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A cancer-predisposing "hot spot" mutation of the fumarase gene creates a dominant negative protein.
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A cancer-predisposing "hot spot" mutation of the fumarase gene creates a dominant negative protein.
A cancer-predisposing "hot spot" mutation of the fumarase gene creates a dominant negative protein. Int J Cancer. 2008 Feb 15; 122(4):947-51.
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PubMed
subject areas
Blotting, Western
Cells, Cultured
Fibroblasts
Fumarate Hydratase
Genes, Dominant
Humans
Lentivirus
Mitochondria
Mutagenesis
Mutation, Missense
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger
Skin