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Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists.
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Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists.
Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists. Bioorg Med Chem Lett. 2007 Oct 01; 17(19):5396-9.
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subject areas
Animals
Calcium
CHO Cells
Cricetinae
Cricetulus
Cyclooxygenase 2 Inhibitors
Excitatory Amino Acid Antagonists
Indicators and Reagents
Joints
Lactones
Osteoarthritis
Pyridines
Pyrimidines
Rats
Receptors, Metabotropic Glutamate
Structure-Activity Relationship
Sulfones