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A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition.
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A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition.
A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. Cancer Discov. 2013 Mar; 3(3):350-62.
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PubMed
subject areas
Cell Line, Tumor
Cell Proliferation
Drug Resistance, Neoplasm
Humans
MAP Kinase Signaling System
Melanoma
Mutation
Neurofibromin 1
Protein Kinase Inhibitors
Proto-Oncogene Proteins B-raf
RNA Interference
authors with profiles
Eliezer Mendel Van Allen, M.D.
Nikhil Wagle, M.D.