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Grb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of Akt-mediated gene repression.
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Grb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of Akt-mediated gene repression.
Grb7 upregulation is a molecular adaptation to HER2 signaling inhibition due to removal of Akt-mediated gene repression. PLoS One. 2010 Feb 02; 5(2):e9024.
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subject areas
Adaptation, Physiological
Animals
Antineoplastic Agents
Blotting, Western
Breast Neoplasms
Cell Line, Tumor
Cell Movement
Cell Survival
Female
Gene Expression Regulation, Neoplastic
GRB7 Adaptor Protein
Humans
Mammary Neoplasms, Experimental
Mice
Mice, Inbred BALB C
Mice, Nude
Phosphatidylinositol 3-Kinases
Proto-Oncogene Proteins c-akt
Quinazolines
Receptor, erbB-2
Reverse Transcriptase Polymerase Chain Reaction
RNA Interference
Signal Transduction
Transplantation, Heterologous
Up-Regulation