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Is the sulphonamide radical in the celecoxib molecule essential for its analgesic activity?

Gassani BC, Rezende RM, Paiva-Lima P, Ferreira-Alves DL, dos Reis WG, Bakhle YS, de Francischi JN. Is the sulphonamide radical in the celecoxib molecule essential for its analgesic activity? Pharmacol Res. 2010 Nov; 62(5):439-43.

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.