Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis.
Dai C, Santagata S, Tang Z, Shi J, Cao J, Kwon H, Bronson RT, Whitesell L, Lindquist S. Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis. J Clin Invest. 2012 Oct; 122(10):3742-54.
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Active Transport, Cell Nucleus
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Animals
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Cell Line, Tumor
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Cell Transformation, Neoplastic
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DNA-Binding Proteins
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Gene Expression Regulation, Neoplastic
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Gene Knockdown Techniques
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Genes, Neurofibromatosis 1
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Hot Temperature
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Humans
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Leupeptins
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Macrolides
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MAP Kinase Signaling System
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Neoplasm Proteins
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Nerve Sheath Neoplasms
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Neurofibromin 1
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NIH 3T3 Cells
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Phosphorylation
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Protein Processing, Post-Translational
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RNA, Messenger
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RNA, Neoplasm
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RNA, Small Interfering
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Transcription Factors
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Withanolides