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Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop.
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Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop.
Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop. Nat Med. 2012 Mar 04; 18(4):529-37.
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PubMed
subject areas
Animals
Autoantigens
Breast Neoplasms
Caspase 3
Cell Adhesion Molecules
Cell Polarity
Cell Proliferation
Cell Transformation, Neoplastic
Computational Biology
Disease Progression
Doxycycline
Female
Flow Cytometry
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Homeodomain Proteins
Humans
Ki-67 Antigen
Luminescent Proteins
Membrane Proteins
Mice
Mice, SCID
Mitogen-Activated Protein Kinases
Oligonucleotide Array Sequence Analysis
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Proto-Oncogene Proteins c-myc
Receptor, erbB-2
RNA, Small Interfering
Signal Transduction
src Homology Domains
Time Factors
Transcription Factors
Tumor Cells, Cultured
authors with profiles
Stephen J. Elledge, Ph.D.