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Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage.
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Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage.
Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage. J Biol Chem. 2001 Aug 10; 276(32):30018-23.
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PubMed
subject areas
Amyloid beta-Protein Precursor
Amyloid Precursor Protein Secretases
Animals
Aspartic Acid Endopeptidases
Binding, Competitive
Biotinylation
Blotting, Western
Cell Nucleus
Culture Media, Conditioned
Dose-Response Relationship, Drug
Endopeptidases
Enzyme Activation
Enzyme-Linked Immunosorbent Assay
Humans
Immunoblotting
Ligands
Luciferases
Membrane Proteins
Mice
Mice, Transgenic
Models, Biological
Neurons
Presenilin-1
Protein Binding
Protein Structure, Tertiary
Receptor, Notch1
Receptors, Cell Surface
Time Factors
Transcription Factors
Transfection
authors with profiles
Oksana Berezovska, Ph.D.
Bradley Theodore Hyman, M.D., Ph.D.