Conformational restriction approach to ß-secretase (BACE1) inhibitors: effect of a cyclopropane ring to induce an alternative binding mode.
Yonezawa S, Yamamoto T, Yamakawa H, Muto C, Hosono M, Hattori K, Higashino K, Yutsudo T, Iwamoto H, Kondo Y, Sakagami M, Togame H, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S. Conformational restriction approach to ß-secretase (BACE1) inhibitors: effect of a cyclopropane ring to induce an alternative binding mode. J Med Chem. 2012 Oct 25; 55(20):8838-58.