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Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice.
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Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice.
Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice. J Clin Invest. 2012 May; 122(5):1677-87.
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subject areas
Activating Transcription Factor 3
Adaptor Proteins, Vesicular Transport
Animals
Apolipoproteins B
Base Sequence
Binding Sites
Down-Regulation
Gene Expression Regulation
Humans
Lipid Metabolism
Lipoproteins, VLDL
Liver
Mice
Mice, Inbred C57BL
Mice, Obese
Multiprotein Complexes
Obesity
Promoter Regions, Genetic
Proteins
Sirolimus
Sterol Regulatory Element Binding Protein 1
TOR Serine-Threonine Kinases
Transcription, Genetic
Triglycerides