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IDH mutation impairs histone demethylation and results in a block to cell differentiation.
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IDH mutation impairs histone demethylation and results in a block to cell differentiation.
IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature. 2012 Feb 15; 483(7390):474-8.
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PubMed
subject areas
3T3-L1 Cells
Adipocytes
Animals
Astrocytes
Cell Differentiation
Cell Line, Tumor
Cell Lineage
DNA Methylation
Enzyme Induction
Gene Expression Regulation
Glioma
Glutarates
HEK293 Cells
Histones
Humans
Isocitrate Dehydrogenase
Jumonji Domain-Containing Histone Demethylases
Methylation
Mice
Mutation
Neural Stem Cells
Promoter Regions, Genetic
authors with profiles
Patrick Shea Ward, M.D.,Ph.D.